Treatment: dapsone (Disulone)

Laboratory tests

• FBC with reticulocyte count
• G6PD assay
• AST
• ALT
• Serum creatinine with eGFR

Every week during the first month (first check on day 8)

• FBC with reticulocyte count
• Methaemoglobin level

At 1 month, in addition

• AST
• ALT
• Serum creatinine with eGFR
• Serum ferritinif neededIn long-term treatment, the SmPC (RCP) asks for transferrin saturation, ferritin and liver function tests one month after the start and then periodically, to detect iron excess linked to the ferrous oxalate in the tablet and to haemolysis ^[2].
• Transferrin saturationif neededIn long-term treatment, the SmPC (RCP) asks for transferrin saturation, ferritin and liver function tests one month after the start and then periodically, to detect iron excess linked to the ferrous oxalate in the tablet and to haemolysis ^[2].

Every month, from the 2nd to the 6th month

• FBC with reticulocyte count

Then every 3 months

• FBC with reticulocyte count
• AST
• ALT
• Serum creatinine with eGFR
• Serum ferritin and transferrin saturation (periodically, long-term treatment)if neededThe ferrous oxalate in the tablet and haemolysis expose to iron overload and liver damage: transferrin saturation, ferritin and liver function tests one month after the start and then periodically ^[2].
• Fructosamine (diabetic patient: if HbA1c does not match plasma glucose readings)if neededOn dapsone, HbA1c may be underestimated because of haemolysis or methaemoglobinaemia; the SmPC (RCP) then advises fructosamine ^[2]. NABM procedure 1576, not combinable with HbA1c (1577) ^[6].