Parkinson's disease

• In this situation, no routine laboratory test is recommended
• Vitamin B12if needednon-French guidelineThe German recommendation (DGN 2023, S2k expert consensus) asks, before starting levodopa-carbidopa intestinal gel by pump, for an electrophysiological search for neuropathy and measurement of vitamins B6, B12 and folate, checked thereafter throughout treatment and corrected if low ^[2]. The HAS guide (2016) does not address this point ^[1].
• Folateif needednon-French guidelineThe German recommendation (DGN 2023, S2k expert consensus) asks, before starting levodopa-carbidopa intestinal gel by pump, for an electrophysiological search for neuropathy and measurement of vitamins B6, B12 and folate, checked thereafter throughout treatment and corrected if low ^[2]. The HAS guide (2016) does not address this point ^[1].
• Vitamin B6if needednon-French guidelineThe German recommendation (DGN 2023, S2k expert consensus) asks, before starting levodopa-carbidopa intestinal gel by pump, for an electrophysiological search for neuropathy and measurement of vitamins B6, B12 and folate, checked thereafter throughout treatment and corrected if low ^[2]. The HAS guide (2016) does not address this point ^[1].

Laboratory tests

• Serum creatinine with eGFR
• CRP (marker of inflammation)
• Not a laboratory test: echocardiography (valvular disease), pulmonary function tests, chest X-ray.

Laboratory tests

• Caeruloplasmin
• Serum copper
• 24-hour urinary copper
• ASTif needednon-French guidelineThe summary of the American recommendation (AASLD 2022) pairs, to investigate suspected Wilson's disease, liver function tests, an FBC and an INR with caeruloplasmin and 24-hour urinary copper ^[8]. The HAS guide cites liver involvement and confirms the diagnosis by copper studies ^[1]. In France, the prothrombin time code outside vitamin K antagonist treatment also gives the INR where relevant ^[5].
• ALTif needednon-French guidelineThe summary of the American recommendation (AASLD 2022) pairs, to investigate suspected Wilson's disease, liver function tests, an FBC and an INR with caeruloplasmin and 24-hour urinary copper ^[8]. The HAS guide cites liver involvement and confirms the diagnosis by copper studies ^[1]. In France, the prothrombin time code outside vitamin K antagonist treatment also gives the INR where relevant ^[5].
• FBCif needednon-French guidelineThe summary of the American recommendation (AASLD 2022) pairs, to investigate suspected Wilson's disease, liver function tests, an FBC and an INR with caeruloplasmin and 24-hour urinary copper ^[8]. The HAS guide cites liver involvement and confirms the diagnosis by copper studies ^[1]. In France, the prothrombin time code outside vitamin K antagonist treatment also gives the INR where relevant ^[5].
• PTif needednon-French guidelineThe summary of the American recommendation (AASLD 2022) pairs, to investigate suspected Wilson's disease, liver function tests, an FBC and an INR with caeruloplasmin and 24-hour urinary copper ^[8]. The HAS guide cites liver involvement and confirms the diagnosis by copper studies ^[1]. In France, the prothrombin time code outside vitamin K antagonist treatment also gives the INR where relevant ^[5].