Lichen planus (skin, oral or genital): hepatitis C and lipid profile
BioMG follows French guidelines. Adapt it to the guidelines and the tests available where you practise.
Diagnosed lichen planus: initial tests
Laboratory tests
- Hepatitis C serology (if never screened)
- Wording to put on the request: "perform HCV RNA as a matter of course if anti-HCV antibodies are positive".
- Hepatitis B serology (HBsAg, anti-HBc, anti-HBs)if neededThe association between lichen planus and hepatitis B remains uncertain [2]. Combined HBV, HCV and HIV screening is recommended by AFEF [3].
- HIV serology (combined screening, if never done)if neededThe association between lichen planus and hepatitis B remains uncertain [2]. Combined HBV, HCV and HIV screening is recommended by AFEF [3].
- Lipid profile (if not done recently)
- TSH (if clinical signs of thyroid dysfunction)if needednon-French guidelineThyroid diseases are more frequent in oral lichen planus [1]; European recommendations do not ask for routine thyroid tests [1].
- ASTif needednon-French guidelineThe American Family Physician (2011) has HCV risk factors looked for and asks for anti-HCV antibodies and liver enzymes in every patient with lichen planus [4]. The European recommendation does not provide for this test [1], and the French sources cited do not ask for it [3,5].
- ALTif needednon-French guidelineThe American Family Physician (2011) has HCV risk factors looked for and asks for anti-HCV antibodies and liver enzymes in every patient with lichen planus [4]. The European recommendation does not provide for this test [1], and the French sources cited do not ask for it [3,5].
Sources (14)
- Ioannides D, Vakirlis E, Kemeny L, Marinovic B, Massone C, Murphy R, et al. European S1 guidelines on the management of lichen planus: a cooperation of the European Dermatology Forum with the European Academy of Dermatology and Venereology. J Eur Acad Dermatol Venereol. 2020;34(7):1403-14.
- Guida S, Tamburelli M, Podo-Brunetti A, Rongioletti F. Lichen planus is associated with hepatitis C but not with hepatitis B virus: a systematic review and meta-analysis with a focus on Italian data. Ital J Dermatol Venerol. 2026;161(1):57-64.
- Association française pour l'étude du foie (AFEF). Recommandations pour le diagnostic et le suivi non-invasif des maladies chroniques du foie. 2020. Chapitre 3, question 1 (dépistage du VHC).
- Usatine RP, Tinitigan M. Diagnosis and Treatment of Lichen Planus. Am Fam Physician. 2011;84(1):53-60.
- Campana F, Lan R, Girard C, et al. French guidelines for the management of oral lichen planus (excluding pharmacological therapy). Ann Dermatol Venereol. 2022;149(1):14-27.
- Lodi G, Pellicano R, Carrozzo M. Hepatitis C virus infection and lichen planus: a systematic review with meta-analysis. Oral Dis. 2010;16(7):601-12.
- García-Pola M, Rodríguez-Fonseca L, Suárez-Fernández C, Sanjuán-Pardavila R, Seoane-Romero J, Rodríguez-López S. Bidirectional association between lichen planus and hepatitis C: an update systematic review and meta-analysis. J Clin Med. 2023;12(18):5777.
- Edwards SK, Bunker CB, van der Snoek EM, van der Meijden WI. 2022 European guideline for the management of balanoposthitis. J Eur Acad Dermatol Venereol. 2023;37(6):1104-17.
- Lai YC, Yew YW, Schwartz RA. Lichen planus and dyslipidemia: a systematic review and meta-analysis of observational studies. Int J Dermatol. 2016;55(5):e295-304.
- US Preventive Services Task Force. Hepatitis C Virus Infection in Adolescents and Adults: Screening. Final Recommendation Statement, 2 mars 2020 (grade B).
- Gemeinsamer Bundesausschuss (G-BA, Allemagne). Richtlinie über die Gesundheitsuntersuchungen zur Früherkennung von Krankheiten (Gesundheitsuntersuchungs-Richtlinie), partie III, version entrée en vigueur le 12 février 2021.
- National Institute for Health and Care Excellence. Hepatitis B and C testing: people at risk of infection. Public health guideline PH43, 12 décembre 2012, mise à jour du 1er mars 2013.
- British Association of Dermatologists. Lichen planus. Patient information leaflet, mise à jour de mars 2024.
- Chen J, Oakley A, Liu J. Lichen planus. DermNet (Nouvelle-Zélande), 2022, mise à jour mineure de 2023.