Peripheral arterial disease

Fasting laboratory tests

• FBC
• Serum creatinine with eGFR
• Lipid profile
• Fasting plasma glucose
• Lipoprotein(a) [Lp(a)], once in a lifetime (not reimbursed in France)if neededIf never measured: ESC 2024 includes Lp(a), at least once in a lifetime, in the laboratory tests for arterial disease ^[2]. HAS does not list it ^[3]. See the page “Dyslipidaemia”.
• HbA1c (known diabetes)if neededKnown diabetes: ESC 2024 lists HbA1c among the tests ^[2]; HAS retains only plasma glucose ^[3]. In a patient without known diabetes, HbA1c is not covered by the French laboratory fee schedule (NABM) (monitoring of glycaemic control only) ^[4].
• ALT (if a statin is to be started)if needednon-French guidelineA statin is indicated in arterial disease ^[5,6]: NICE has transaminases measured before any statin, without ruling out treatment below 3 times normal ^[7], and ESC 2024 lists liver function tests among the tests for arterial disease ^[2]. The HAS list for ALD does not list them ^[3]. The Netherlands do not provide for routine monitoring under statins ^[8]. See the page “Dyslipidaemia”.

Urine tests

• Urine protein:creatinine ratio (spot sample)
• Urine albumin:creatinine ratio (spot sample) (if diabetes or hypertension)if neededDiabetes or hypertension: HAS prefers albuminuria to proteinuria in these situations ^[3]. In the Netherlands, this ratio is part of the cardiovascular risk profile, with no requirement for diabetes or hypertension ^[8]; HAS reserves it for these two situations ^[3].